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Among people diagnosed with Alzheimer’s, researchers recognize familial forms of the disease and sporadic cases. This shifting appreciation of inherited risk, researchers say, is due to a better understanding of the role of a fourth gene that carries the blueprints to make a lipid-carrying protein called apolipoprotein E, known as APOE. One known as APOE2 is thought to be protective against the development of Alzheimer’s disease. They also compared people with two copies of APOE4 to people with other inherited forms of the disease — early-onset autosomal dominant Alzheimer’s disease (ADAD) and Down syndrome-associated Alzheimer’s disease (DSAD). Gene testing isn’t currently recommendedIt is also likely to change how people who carry the APOE4 gene are diagnosed and treated.
Persons: APOE4, , Dr, Juan Fortea, Sant, Fortea, Charles Bernick, Bernick, Alzheimer’s wasn’t, isn’t, they’re, ” Fortea, Sanjay Gupta, Reisa Sperling, , ” Sperling, ” Dr, Sterling Johnson, Johnson Organizations: CNN, Nature, National Alzheimer’s Coordinating, Neurology, Hospital de, Cleveland Clinic Lou, Brain Health, CNN Health, Alzheimer’s Research, Brigham, Women’s, Alzheimer’s, University of Wisconsin Locations: Alzheimer’s, Spain, United States, Santa, Barcelona, Wisconsin
These proteins cause the walls of a person’s blood vessels to keep growing and thicken over time. As the blood vessels narrow, the heart is forced to work harder to pump blood to the lungs. Treatment with a combination of drugs that dilate, or relax, blood vessels can improve this outlook, but they are not a cure. Both groups were also taking the standard medications for the condition, which help relax blood vessels to improve blood flow. But Galiatsatos said that as promising as the drug looks, there are still many unknowns, including whether the drug will benefit all PAH patients equally.
Persons: Katrina Barry, Barry, , , Winrevair, Merck Winrevair, Vallerie McLaughlin, Panagis, Galiatsatos, isn’t, ” Barry, I’m, fanny, She’s, sotatercept, PAH, Sotatercept, “ There’s, Kristin Highland, Highland, ” Merck, Merck, Dr, Sanjay Gupta, Aaron Waxman, Barry’s, he’s, they’ve, Johnson –, Waxman, “ I’ve, “ It’s, who’ve Organizations: CNN, American Lung Association, US Food and Drug Administration, Merck, FDA, University of Michigan, PAH, Johns Hopkins Bayview Medical Center, New England, of Medicine, Cleveland Clinic, Institute, Clinical, CNN Health, Brigham, Women’s Hospital, Johnson Locations: PAH, American, Greece, Boston
You may be eating predigested food. Here’s why
  + stars: | 2024-02-01 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +11 min
Aleksandr Zubkov/Moment RF/Getty ImagesBypassing the digestive systemMuch like the regurgitated food mother birds feed their babies in the nest, ultraprocessed food is quick and easy to digest, according to experts. “So the question is, which degree of processing remains compatible with human food system sustainability and global health? Some food processing may be goodHumans have processed food for centuries — the first evidence of fermentation was some 13,000 years ago. Alexander Donin/iStockphoto/Getty ImagesThe ingredients used in many ultraprocessed foods, however, have been subjected to much more than a bit of heat. “The other way I put it is that individuals who are trying to control their weight in today’s food environment are fighting an entire food system on their own.
Persons: starchy, , , Chris van Tulleken, van Tulleken, Aleksandr Zubkov, that’s, didn’t, David Katz, ” Katz, we’ve, ’ you’ve, it’s, Kevin Hall, Hall, ” Hall, Giulia Menichetti, Menichetti, Anthony Fardet, Fardet, ” Fardet, Alexander Donin, Marion Nestle, Paulette Goddard, ” Nestle Organizations: CNN, Industry, University College London, BBC, Getty, True Health Initiative, National Institute of Diabetes, Diseases, Harvard Medical School, Brigham, Women’s Hospital, Network Science Institute, Northeastern University, French National Institute for Agricultural Research, New York University Locations: Europe, United States, Bethesda , Maryland, Boston, Paris
Daily Multivitamin Might Help Aging Brains
  + stars: | 2024-01-18 | by ( Jan. | At P.M. | ) www.usnews.com   time to read: +5 min
By Dennis Thompson HealthDay Reporter(HealthDay)THURSDAY, Jan. 18, 2024 (HealthDay News) -- A daily multivitamin could help people keep their brains healthy as they age, a new trial finds. Results suggest taking multivitamins could help prevent memory loss and slow cognitive aging among older adults, researchers report in the Jan. 18 issue of the American Journal of Clinical Nutrition. The effect was measurable: A daily multivitamin slowed brain aging by the equivalent of two years compared to placebo. “Cognitive decline is among the top health concerns for most older adults, and a daily supplement of multivitamins has the potential as an appealing and accessible approach to slow cognitive aging,” he said. It looked at whether a special cocoa extract supplement, a daily multivitamin (in this case Centrum Silver) or both might help boost health.
Persons: Dennis Thompson, Dr, Richard Caselli, , Chirag, , ” Yvas, Olivia Okereke, Preventive Medicine Howard Sesso, Zaldy Tan, ” Tan, Caselli, Sesso, Brigham Organizations: American, Clinical Nutrition, Mayo Clinic, NBC News, Chirag Vyas, Massachusetts General Hospital’s Department of Psychiatry, Cocoa, Massachusetts General Hospital, MGH, Brigham, Women’s Hospital, Columbia University, Wake Forest University, National Institutes of Health, Mars Inc, Pfizer, COSMOS, Women’s, Preventive Medicine, Council for Responsible Nutrition, Cleveland Clinic, NBC Locations: Arizona, Massachusetts, multivitamins, Jona, Los Angeles
Cancer Deaths Are Falling, but There May Be an Asterisk
  + stars: | 2024-01-17 | by ( Gina Kolata | ) www.nytimes.com   time to read: +1 min
The cancer society highlighted three chief factors in reduced cancer deaths: declines in smoking, early detection and greatly improved treatments. Breast cancer mortality is one area where treatment had a significant impact. That includes metastatic cancer, which counted for nearly 30 percent of the reduction in the breast cancer death rate. Breast cancer treatment has improved so much that it has become a bigger factor than screening in saving lives, said Ruth Etzioni, a biostatistician at the Fred Hutchinson Cancer Center. “The biggest untold story in breast cancer is how much treatment has improved,” said Dr. H. Gilbert Welch, a cancer epidemiologist at Brigham and Women’s Hospital.
Persons: , , Donald Berry, Sylvia K, Plevritis, Ruth Etzioni, Mette Kalager, H, Gilbert Welch Organizations: University of Texas, Anderson Cancer Center, Stanford University, Fred Hutchinson Cancer Center, University of Oslo, Oslo University Hospital, Brigham, Women’s
Now the edifice may finally be cracking: The #MeToo movement is picking up pace in the medical profession. Dr. Hadden was an obstetrician-gynecologist who was first arrested when a patient called the police and reported that he had licked her genitals during an exam. Though I was working at the medical center while the accusations unfurled, I wasn’t aware of them until more recently. Even after Dr. Hadden was found guilty, Columbia did not notify all of his patients about his behavior. On Nov. 23, the one-year look-back window closes for past patients to sue Dr. Hadden and the medical center.
Persons: it’s, Darius Paduch, Zhi Alan Cheng, Derrick Todd, Brigham, Cheng, Todd, Dr, Robert Hadden, Hadden, Newman’s, Aja Newman, Newman, Dr . Hadden, HIPAA, . Hadden Organizations: Presbyterian Queens Hospital, Harvard, Women’s, Columbia, New York Locations: New York, NewYork, Columbia, Sinai
Respiratory illness season is coming up, and that’s going to be a huge issue,” said David Margraf, a pharmaceutical research scientist with the University of Minnesota’s Resilient Drug Supply Project. During a drug shortage, allocation helps ensure that no single buyer can claim all the available supply. Khazanchi and his colleague Dr. Ryan Brewster recently studied the clinical effects of last winter’s amoxicillin shortage. “Drug shortages will likely continue to increase if the pricing dynamics in the marketplace are not addressed,” Sandoz said in a statement. “The companies refuse to tell us what’s going on,” said Erin Fox, who tracks drug shortages at the University of Utah.
Persons: , earaches, , David Margraf, Selena Ko, Erin Hooley, pediatricians, Rohan Khazanchi, Khazanchi, Ryan Brewster, Amoxicillin, ” Khazanchi, “ It’s, ” Sandoz, Erin Fox, Laura Bray, They’re, ” Margraf, ” Bray, Dr, Sanjay Gupta, , Matt Christian Organizations: CNN, Food, University of, Project, Rush University Medical Center, Chicago Tribune, TNS, Getty, FDA, Brigham & Women’s Hospital, Teva Pharmaceuticals, Novartis, University of Utah, Angels, CNN Health, US Department of Agriculture, Pharmacopeia’s Medicines Locations: Chicago, Boston
While researchers found significant associations between developing diabetes in night owls who worked during the day, they did not find an association for night owls who went to work later in the day or worked overnight shifts. One published in June found night owls were more likely to die early, mostly due to bad habits they developed when they stayed up late, such as drinking and smoking. A 2022 study determined night owls were more sedentary, had lower aerobic fitness levels and burned less fat at rest and while active than early birds. Night owls were also more likely to be insulin-resistant, a precursor to diabetes. Night owls have higher levels of visceral body fat in the abdominal region, a key risk factor for type 2 diabetes and heart disease.
Persons: , Sina Kianersi, ” Kianersi, Kianersi, Bhanu Prakash Kolla, ” Kolla, that’s, , chronotype, Tianyi Huang Organizations: CNN, Brigham, Women’s Hospital, Harvard Medical School, Center for Sleep Medicine, Mayo Clinic, Internal, Nurses, BMI, Women’s Locations: Boston, Rochester , Minnesota
Since his death, Texas-based manufacturer Paqui has asked retailers to stop selling the individually wrapped chips, a step 7-Eleven has already taken. The One Chip Challenge chip sells for about $10 and comes wrapped in a sealed foil pouch that is enclosed in a coffin-shaped cardboard box. Authorities in Massachusetts also have responded by warning parents about the challenge, which is popular on social media sites such as TikTok. Family and friends of Wolobah believe the chips caused his death and his family called for the chips to be banned from store shelves. In addition to its name, One Chip Challenge, the package lays out the challenge rules, which encourage the buyer to eat the entire chip, “wait as long as possible before drinking or eating anything” and post their reaction on social media.
Persons: Harris, Paqui, Attorney Joseph Early, , Lauren Rice, Dr, Peter Chai, ” Chai, Wolobah, Douglas Hill, , Douglas Organizations: The Hershey Company, Authorities, Attorney, Paramedics, Tufts Medical Center, Brigham, Women’s Hospital, ” Police Locations: WORCESTER, Massachusetts, Texas, Worcester, Worcester County, California, Minnesota, Boston, Liberia
(AP) — The maker of an extremely spicy tortilla chip sold as the One Chip Challenge and popularized as a dare on social media is pulling the product after the family of a Massachusetts teenager blamed the stunt for his death. The One Chip Challenge chip sells for about $10 and comes wrapped in a sealed foil pouch that is enclosed in a coffin-shaped cardboard box. Political Cartoons View All 1148 ImagesAuthorities in Massachusetts have also responded to the death by warning parents about the challenge, which is is popular on social media sites such as TikTok. Family and friends of Wolobah believe the chips caused his death, and his family called for the chips to be banned from store shelves. In addition to its name, One Chip Challenge, the package lays out the “rules for the challenge,” which encourages the buyer to eat the entire chip, “wait as long as possible before drinking or eating anything,” and post their reaction on social media.
Persons: Harris Wolobah's, hasn't, Attorney Joseph Early, , Lauren Rice, Dr, Peter Chai, Wolobah, Douglas Hill, , Douglas Organizations: The Hershey Company, Attorney, Tufts Medical Center, Brigham, Women’s, ” Police Locations: WORCESTER, Massachusetts, Texas, Worcester County, California, Minnesota, Boston, Worcester, Liberia
Lilly expects the U.S. Food and Drug Administration to decide by the end of this year whether to approve donanemab. The company had previously reported that 24% of the overall donanemab treatment group had brain swelling. The deaths of three trial patients were linked to the treatment, researchers reported. For high tau patients, donanemab was shown to slow disease progression by about 17%, while the benefit was 35% for those with low-to-intermediate tau levels. Both medications are also being studied in large trials to see if they have an impact on delaying onset of Alzheimer's disease symptoms.
Persons: Seth Gale, Brian Snyder, Eli Lilly, Anne White, Lilly, Susan Kohlhaas, Liana Apostolova, White, Liz Coulthard, donanemab, Deena Beasley, Ludwig Burger, Will Dunham, Bill Berkrot, Caroline Humer Organizations: Alzheimer Research, Brigham, Women’s, REUTERS, Alzheimer's Association International, U.S . Food, Drug Administration, Alzheimer’s Research, Indiana University School of Medicine, Doctors, University of Bristol, JAMA, FDA, Alzheimer's Association, Health Organization, New York Stock Exchange, Thomson Locations: Boston , Massachusetts, U.S, Amsterdam, Eisai
CNN —If TikTok and Reddit influencers are to be believed, the plant-based compound called berberine can be a replacement for such popular diabetes and weight loss drugs as Ozempic and Wegovy. Is berberine’s weight loss effect meaningful? Berberine may enhance the body’s natural production of GLP-1, or glucagon-like peptide 1, a gastrointestinal hormone that’s used in Ozempic and other new weight loss drugs. However, in terms of its weight loss benefits, they are modest at best,” he said. “Metformin lowers blood sugar, and berberine lowers blood sugar,” Levitt said.
Persons: Berberine, , , Caroline Apovian, Justin Ryder, Ryder, Joshua Levitt, Ashurbanipal, ” Levitt, Gaston Ernesto Gonzalez Avila, Levitt Organizations: CNN, US Food and Drug Administration, Harvard Medical School, Center, Weight Management, Wellness, Brigham, Women’s Hospital, Northwestern University’s Feinberg School of Medicine, BMI, National Library of Medicine, FDA, American Chemical Society Locations: Boston, Chicago, Ayurveda, Hamden , Connecticut
“This study captures why obesity is a disease — there are actual changes to the brain,” said Apovian, who was not involved in the study. They wanted to know if that would be different in people with obesity compared to those of normal weight. At the same time, levels of dopamine rose in those at normal weight, signaling that the reward centers of the brain were also activated. Losing weight did not reset the brain in people with obesity, Serlie said. Until science answers these questions, the study emphasizes, once again, that weight stigma has no place in the fight against obesity, Serlie said.
Persons: ’ ”, Caroline Apovian, , Apovian, Sadaf, they’ve, , Mireille Serlie, ” Faroof, ” Serlie, Farooqi, Serlie, it’s, ” Farooqi, Organizations: CNN, Harvard Medical School, Center, Weight Management, Wellness, Brigham, Women’s Hospital, BMI, University of Cambridge, Yale School of Medicine Locations: Boston, New Haven , Connecticut
CNN —When Sam Maya, a beloved husband, father, friend, stockbroker and coach, died by suicide 16 years ago, he left a note. Maya spent nearly a decade writing "Sushi Tuesdays," which aims to humanize the face of suicide. Post Hill PressShe spent nearly a decade writing “Sushi Tuesdays,” beginning with a blog by the same name, an homage to the weekly ritual she created after her husband’s death. When Sam Maya died, Tasheff was a single mother living on a budget in Brooklyn and couldn’t travel to California to visit. Maya continues to honor her Tuesdays with therapy and yoga, a hike with a friend, and sometimes a sushi lunch.
Persons: Sam Maya, Charlotte, Charlotte Maya, Maya, Ashwini, Nadkarni, , , Sam, ” Maya, Gregory Stratz, Tim Stratz, Jason Maya, Parker, Danny Maya, Daniel Stratz, Karen Ray, they’d, The, Jane Doe, Jane, she’s, Jane ”, Bess ”, Katherine Tasheff, Tasheff, swiftness, Daniel, Daniels, , Lauren Kerwin, Kerwin Organizations: CNN, Post, Press, US Centers for Disease Control, CDC, Research, Brigham, Women’s Hospital, Psychological, Karen Ray Photography, Rice University, American Foundation for Suicide Locations: Boston, Maya’s, Brooklyn, California
CNN —President Joe Biden will nominate Dr. Monica Bertagnolli, who currently leads the National Cancer Institute, to be the next director of the National Institutes of Health, the White House announced on Monday. Biden called Bertagnolli “a world-class physician-scientist whose vision and leadership will ensure NIH continues to be an engine of innovation to improve the health of the American people,” in a statement Monday. She would lead the country’s medical research agency, overseeing 27 research institutes and centers focused on different areas of medical research, such as cancer, the human genome, as well as allergy and infectious diseases. The nomination to lead NIH marks a fast ascent within the Biden administration for Bertagnolli. In this August 2022 photo, Monica Bertagnolli, newly appointed director of the National Cancer Institute, stands for recognition during remarks by President Joe Biden.
How to Respond to a Stranger in Mental Distress
  + stars: | 2023-05-05 | by ( Dani Blum | Dana G. Smith | ) www.nytimes.com   time to read: +2 min
If you are concerned for your safety, the best course of action is usually to leave the situation as soon as possible, said Schroeder Stribling, the president and chief executive of Mental Health America, a nonprofit group focused on advancing mental health. If you’re on the subway, for example, change cars, or get off and wait for the next train. Many cities have help lines and mobile crisis response teams that serve as an interface between the police and mental health providers and are trained to help people in acute distress. In New York City, for example, you can call 888-NYC-WELL to connect with mental health professionals. If you call 911, specify that you are calling about a mental health emergency and request a crisis intervention team if one is available, said Megan Rochford, the director of the National Alliance on Mental Illness HelpLine Operations.
The drug, donanemab, met all goals of the trial. "These are the strongest phase 3 data for an Alzheimer's treatment to date," said Maria Carrillo, chief science officer for the Alzheimer's Association. In the donanemab treatment group, Lilly said brain swelling, a known side effect of drugs of this type, occurred in 24% of the participants, with 6.1% experiencing symptoms. In the Leqembi Phase 3 trial, the drug was associated with brain swelling in nearly 13% of its study participants. It also said 47% of donanemab patients in the 18-month trial had no disease progression at 12 months, compared with 29% of the placebo group.
The Boston Marathon is arguably the most elusive finish line of all, and not just anyone can cross it. In 2013, on a cool, partly sunny day, this ebullient scene was shattered when two bombs exploded near the finish line. On Monday, nearly 30,000 runners will journey, down and up and down, toward the finish line of the 127th Boston Marathon. Volunteer, runner I used to volunteer at the finish line, reading information about runners as they finished for the announcer. It means something so different crossing that finish line compared to other marathon majors.
CNN —As the Supreme Court prepares for yet another controversial abortion case to come its way, the justices will pore over District Court Judge Matthew Kacsmaryk’s ruling last week to block the government’s approval of the key medication abortion drug at issue. “There are serious questions on whether the Supreme Court is willing to endorse the district’s court’s very broad approach to those questions,” he said. As he often does, Supreme Court Justice Brett Kavanaugh wrote separately last June to explain his thinking in voting to overturn Roe v. Wade. The Supreme Court might also take issue with the relief that Kacsmaryk ordered. None other than the liberals on the Supreme Court who dissented in Dobbs.
A video clip purporting to show a stillborn baby coming back to life while its mother prays is misleading as the Brazilian hospital where the video was recorded in 2020 said then the baby was delivered alive and in good health. A closer look at the video shows the Women’s Hospital logo on the mother’s gown (bit.ly/3RnvZYH), (bit.ly/3Fbxt4R). The foundation managing the hospital (bit.ly/3Jqnj34) released a statement on Sept. 14, 2020 saying the baby was born by normal delivery and in good health. It explained that the woman was “speaking prayers of thanks for the life of her child” when the baby began to cry. The foundation managing the hospital has said the baby in the 2020 video was not stillborn and the woman was praying in thanks for the child.
“If we don’t use them, things don’t work right.”When it comes to blood pressure, moving around helps improve circulation, Diaz said. Blood pressure and blood sugar were measured during each phase of the study. The strategy that worked best was five minutes of walking for every 30 minutes of sitting. All walking strategies resulted in a significant reduction of 4 to 5 blood pressure points, compared to sitting all eight hours. "When you do it without breaks, your blood pressure goes up and there are elevations in blood sugar.”Do standing desks help?
The stark findings underscore that, despite decades of effort, hospitals in the United States still have a long way to go to improve patient safety, experts say. A total of 222 adverse events were considered preventable, meaning an error resulted in patient harm. Twenty-nine people, or 1% of the total of those admitted, experienced serious preventable adverse events that resulted in serious harm. The most common adverse events overall (nearly 40%) were related to medications given in the hospital. It used data from patients hospitalized in New York state in 1984, and found that only about 4% of hospitalized patients experienced harm.
U.S. new drug price exceeds $200,000 median in 2022
  + stars: | 2023-01-05 | by ( Deena Beasley | ) www.reuters.com   time to read: +3 min
The median annual price of the 17 novel drugs the U.S. Food and Drug Administration (FDA) approved since July 2022 is $193,900, down from $257,000 in the first half of 2022, Reuters found. For full year 2022, the median was $222,003. Reuters Graphics Reuters GraphicsIn 2021, the median annual price was $180,000 for the 30 drugs first marketed through mid-July, according to a study published recently in JAMA. Health insurers and other payers often demand discounts and rebates for prescription drugs once competing treatments become available. As patents expire, lower-cost generics also mitigate prescription drug price inflation, which in the 12 months through November 2022 was 1.9%, according to the Bureau of Labor Statistics.
CNN —Early research suggests a promising use of artificial intelligence to predict the 10-year risk of death from a heart attack or stroke from a single chest X-ray. The AI model uses the same risk thresholds as the established risk calculator, and early findings suggest that it works just as well. Sometimes, the AI findings align with a traditional radiology reading, but other times, it picks up on things that may have been missed, he said. He was not involved in the new AI research but says it’s important to keep the field moving forward. “The risk calculator is one part of risk assessment, but it’s not the only part.
Of particular importance is information about how many seniors die, develop disabilities, can no longer live independently, or have a significantly worsened quality of life after major surgery. “What older patients want to know is, ‘What’s my life going to look like?’” Cooper said. Invasive procedures that take place in operating rooms with patients under general anesthesia were counted as major surgeries. Two years ago, Gill’s team conducted research that showed 1 in 3 older adults had not returned to their baseline level of functioning six months after major surgery. This includes assessing older patients three times a day for delirium (an acute change in mental status that often afflicts older hospital patients), getting patients moving as soon as possible, and using non-narcotic pain relievers.
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